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Tweets by ASCPT 2023 Annual Meeting
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EP-002
INTEGRATED METABOLOMICS ANALYSIS REVEALS MECHANISTIC INSIGHTS INTO THE ANCESTRAL DIFFERENCES IN PLASMA RENIN ACTIVITY AMONG PATIENTS WITH HYPERTENSION AND THIAZIDE DIURETICS BLOOD PRESSURE LOWERING EFFECTS.
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EP-004
A SINGLE CENTRE, PROSPECTIVE STUDY TO EVALUATE THE EFFECT OF DOUBLE CARBAPENEM BASED COLISTIN THERAPY VERSUS BEST AVAILABLE THERAPY FOR THE TREATMENT OF CARBAPENEM RESISTANT ENTEROBACTERIACEAE AT A TERTIARY CARE HOSPITAL IN INDIA.
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EP-005
AN OPEN-LABEL BIOEQUIVALENCE STUDY IN HEALTHY VOLUNTEERS TO COMPARE THE PHARMACOKINETICS OF TWO DIFFERENT TABLET STRENGTHS OF SOTORASIB.
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EP-006
AN OPEN-LABEL STUDY TO ASSESS THE EFFECT OF COADMINISTRATION OF SOTORASIB ON THE PHARMACOKINETICS OF ROSUVASTATIN, A BREAST CANCER RESISTANCE PROTEIN SUBSTRATE, IN HEALTHY SUBJECTS.
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EP-007
CENTRAL ADMINISTRATION OF COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT PEPTIDE REDUCES CISPLATIN-INDUCED EMESIS AND C-FOS EXPRESSION IN SUNCUS MURINUS.
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EP-008
POPULATION PHARMACOKINETICS AND EXPOSURE-RESPONSE ANALYSIS OF TREMELIMUMAB 300 MG SINGLE DOSE COMBINED WITH DURVALUMAB 1500 MG EVERY 4 WEEKS (STRIDE) IN UNRESECTABLE HEPATOCELLULAR CARCINOMA.
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EP-010
HYPOXIA INDUCIBLE FACTOR-1A POLYMORPHISMS ASSOCIATED WITH ADVANCED CHRONIC KIDNEY DISEASE.
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EP-013
DEVELOPMENT OF POPULATION PHARMACOKINETICS MODEL OF PYRAZINAMIDE AND OPTIMAL DOSE RECOMMENDATION FOR ELDERLY WITH DIABETES MELLITUS IN KOREAN TUBERCULOSIS PATIENTS.
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EP-014
ESTIMATION OF NOVEL BISPECIFIC T-CELL ENGAGER (BiTE®) MOLECULE PHARMACOKINETICS IN CYNOMOLGUS MONKEY FROM STRUCTURALLY-SIMILAR BiTE MOLECULE DATA.
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EP-015
EXPLAINING INTERPATIENT VARIABILITY OF ADALIMUMAB RESPONSE IN CHRONIC PLAQUE PSORIASIS BY PHARMACOKINETIC-PHARMACODYNAMIC MODELLING: RESULTS FROM THE OPTIMAP STUDY.
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EP-016
GATIFLOXACIN EXPOSURE IN THE LESION AS TARGET SITE OF GATIFLOXACIN IN A RABBIT MODEL OF TUBERCULOSIS: COMPARISON WITH THE OUTCOMES FROM THE PHASE III OFLOTUB TRIAL.
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EP-017
MODEL-INFORMED VANCOMYCIN DOSING TO ADDRESS DELAYED RENAL MATURATION IN INFANTS AND YOUNG CHILDREN WITH CONGENITAL HEART DISEASE.
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EP-018
POPULATION PHARMACOKINETIC ANALYSIS OF RILZABRUTINIB IN HEALTHY SUBJECTS AND PATIENTS WITH PEMPHIGUS.
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EP-021
PBPK MODELING OF A NARROW THERAPEUTIC INDEX DRUG AND APPLICATION IN PREDICTING DOSE ESCALATION SCENARIOS, FOOD EFFECT, DDI AND SPECIAL POPULATION.
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EP-022
SELECTION OF COMPARISON DRUGS FOR ASSESSING THE CARDIAC PROTECTIVE PROPERTIES OF DRUG CANDIDATES.
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EP-023
POPULATION PHARMACOKINETIC MODELLING TO CONFIRM WEIGHT-BASED BANDED DOSING AND EXPOSURE-RESPONSE EFFICACY ANALYSES TO SUPPORT TROFINETIDE TREATMENT IN RETT SYNDROME.
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EP-024
POPULATION PHARMACOKINETIC MODELLING TO PREDICT TROFINETIDE EXPOSURE AND EXPOSURE-RESPONSE SAFETY ANALYSES IN GIRLS WITH RETT SYNDROME AGED 2–4 YEARS.
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EP-025
INDUCED PLURIPOTENT STEM CELLS (IPSCS) AS A MODEL TO STUDY THIOPURINE INDUCED PANCREATITIS: PERSONALIZATION OF THERAPY IN PEDIATRIC PATIENTS WITH INFLAMMATORY BOWEL DISEASE.
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EP-026
MACHINE LEARNING FOR PHARMACOKINETIC/PHARMACODYNAMIC MODELING.
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PT-001
MAXIMUM LIKELIHOOD ESTIMATION OF RENAL TRANSPORTER ONTOGENY PROFILES FOR PEDIATRIC PBPK MODELING.
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PT-002
OPTIMIZING CLINICAL TRIALS FOR DUCHENNE MUSCULAR DYSTROPHY USING MULTIVARIATE DISEASE PROGRESSION MODELS THAT BRIDGE A FUNCTIONAL ENDPOINT AND MRI RELAXOGRAPHY OF FIVE LEG MUSCLES.
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PT-003
EXPRESSION OF ABCB1 IS DECREASED IN PLACENTA OF WOMEN WITH AUTOIMMUNE DISEASE AND IN CYTOKINE- TREATED PLACENTAL EXPLANTS.
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PT-004
PROSPECTIVE VALIDATION OF MAXIMUM A POSTERIORI-BAYESIAN ESTIMATION OF TACROLIMUS EXPOSURE IN STABLE KIDNEY TRANSPLANT RECIPIENTS.
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PT-005
MAJOR POTENTIAL DRUG-DRUG INTERACTIONS AMONG MEDICAID-INSURED CHILDREN IN THE OUTPATIENT SETTING.
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PT-006
A LESION-CENTRIC AND TARGET-SPECIFIC PKPD MODEL OF PYRAZINOIC ACID IN PATIENTS WITH TUBERCULOSIS.
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PT-007
VALIDATING THE PROTECTIVE CONCENTRATION OF PIPERAQUINE FOR MALARIA PREVENTION IN PREGNANT UGANDAN WOMEN.
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PT-008
INFLUENCE OF MCT6 ON PLATINUM DISPOSITION AND OTOTOXICITY.
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PT-009
ASSOCIATION BETWEEN TACROLIMUS AND CYP3A5 GENOTYPE IN PEDIATRIC KIDNEY TRANSPLANT.
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PT-010
PREDICTING LINEZOLID-INDUCED HEMATOLOGIC TOXICITIES IN REAL-WORLD PATIENTS WITH HYBRID MODELING.
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PT-011
COMPUTATIONAL SYSTEMS PHARMACOLOGY OF ANTIBODY-DRUG CONJUGATES.
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PT-012
POPULATION PHARMACOKINETICS OF ISONIAZID IN TBTC STUDY 31/ACTG A5349.
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PT-013
CONCURRENT GABAPENTIN AND OPIOID USE AND RISK OF MORTALITY IN MEDICARE RECIPIENTS WITH NON-CANCER PAIN.
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PT-014
A GLOBAL PROTEOMICS ANALYSIS OF THE ONTOGENY OF THE BLOOD-BRAIN BARRIER.
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PT-015
TRANSPORT AND KINASE DEPENDENT REGULATION OF TYROSINE KINASE INHIBITOR INDUCED CARDIOTOXICITY.
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PT-016
POPULATION PHARMACOKINETIC MODELING TO GUIDE THE OPTIMAL DOSING FOR UNFRACTIONATED HEPARIN IN PEDIATRICS REQUIRING EXTRACORPOREAL MEMBRANE OXYGENATION.
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PT-017
CARDIOVASCULAR SAFETY OF CARFILZOMIB IN KOREA: RETROSPECTIVE COHORT STUDY USING A NATIONWIDE ADMINISTRATIVE CLAIM DATABASE.
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PT-018
OPTIMIZATION OF THE BETAMETHASONE DOSING REGIMEN DURING PREGNANCY: A COMBINED PLACENTA PERFUSION AND PREGNANCY PBPK MODELLING APPROACH.
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PT-019
ROLE OF ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B (OATP1B) IN HEPATIC UPTAKE AND ADVERSE EFFECTS OF AROMATASE INHIBITORS (AIS).
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PT-020
FUNCTIONAL CHARACTERIZATION OF ELAVL2 REVEALED THE ROLE OF POST-TRANSCRIPTIONAL REGULATION IN PSYCHIATRIC DISORDERS AND ANTIDEPRESSANT TREATMENT RESPONSE.
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PT-021
PHARMACOKINETIC (PK) BASIS OF STATIN DRUG-DRUG INTERACTION (DDI) INFORMATION IN FDA LABELS.
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PT-022
OPTIMIZING LUMEFANTRINE DOSING IN YOUNG CHILDREN USING REAL WORLD DATA AND PHARMACOKINETIC/PHARMACODYNAMIC SIMULATIONS.
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PT-023
DEVELOPMENT OF INTRANASAL PHYSIOLOGICALLY BASED NOSE TO BRAIN MODEL AND ITS APPLICATION TO CHARACTERIZE IN NEUROEPO ABSORPTION VIA NASAL ROUTE AND DISTRIBUTION TO LUMBAR CSF IN HEALTHY NON-HUMAN PRIMATES (CYANOMOLGUS MONKEY).
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PT-024
PHARMACOKINETICS AND TISSUE DISTRIBUTION OF A LIPID-BASED EXTENDED-RELEASE NANO-FORMULATION OF MO-OH-NAP TROPOLONE TO ENHANCE PULMONARY DELIVERY.
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PT-025
A NOVEL REGULATORY VARIANT PROMOTES CYP2D6 ALTERNATIVE SPLICING AND REDUCES FULL-LENGTH CYP2D6 PROTEIN LEVELS IN LIVER SAMPLES.
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PT-026
TRANSCRIPTOMIC PROFILING OF PTRPD KNOCK-DOWN IN HUMAN IPSC-DERIVED NEURONS REVEALED A ROLE IN ALCOHOL USE DISORDER DRUG TREATMENT RESPONSE.
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PT-027
DO GLUCOSE-LOWERING DRUGS AFFECT DRUG METABOLISM AND WARFARIN EFFICACY?
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PT-028
CLINICAL ASSESSMENT OF THE DRUG INTERACTION POTENTIAL OF THE PSYCHOTROPIC NATURAL PRODUCT KRATOM (MITRAGYNA SPECIOSA).
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PT-029
BUILDING A TELEHEALTH PHARMACOGENETIC TESTING PROGRAM IN RURAL AND PEDIATRIC PSYCHIATRY.
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E-001
EFFECT OF PAROXETINE OR QUETIAPINE COMBINED WITH OXYCODONE VS OXYCODONE ALONE ON VENTILATION DURING HYPERCAPNIA: A RANDOMIZED CLINICAL TRIAL.
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E-002
FURTHER EVIDENCE ON ABCB1 DRUG TRANSPORTER IN THE RESPONSE TO TEMOZOLOMIDE, CARMUSTINE AND LOMUSTINE IN GLIOBLASTOMA MULTIFORME.
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E-003
ASSESSMENT OF TREATMENT PATHS FOR OUD PATIENTS AFTER AN ACUTE OUD EVENT.
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E-004
EXTRAPOLATION OF EFFICACY OF A DEXTROAMPHETAMINE TRANSDERMAL SYSTEM (d-ATS) FROM PEDIATRIC (PED) TO ADULT POPULATIONS USING PHARMACOKINETIC (PK) MODELING.
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EP-011
METABOLIC PROFILE INVESTIGATION REVEALS WIDE VARIABILITY IN THE EXPOSURE OF ISONIAZID AND ITS HEPATOTOXIC METABOLITES IN TUBERCULOSIS PATIENTS.
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EP-027
EXAMINING THE REGIONAL IMPACT OF FENTANYL ON INFLAMMATORY MEDIATORS WITHIN THE BRAIN IN THE SETTING OF HIV.
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EP-028
EVALUATING THE UTILITY OF PROTEOMICS FOR THE IDENTIFICATION OF CIRCULATING PHARMACODYNAMIC BIOMARKERS OF IFNΒ-1A BIOLOGICS.
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EP-029
IDENTIFICATION OF A SAFE AND TOLERABLE CARBAMAZEPINE DOSING PARADIGM THAT FACILITATES EFFECTIVE CYP3A INDUCTION EVALUATION.
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EP-030
PRECLINICAL IN-VITRO ASSAYS EVALUATING PROTEIN DEGRADERS (PDS) ASSOCIATE WITH ORAL BIOAVAILABILITY AND VOLUME OF DISTRIBUTION IN TISSUES.
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EP-031
PHARMACOKINETIC INTERACTION OF OMEGA-3 FATTY ACID 4 G AND ATORVASTATIN 40 MG.
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EP-032
A FIRST-IN-HUMAN PHASE I STUDY OF THE GFH312 A RIPK1 INHIBITOR, EVALUATING SAFETY/TOLERABILITY AND PHARMACOKINETICS IN HEALTHY SUBJECTS.
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EP-033
A PHASE 1, OPEN-LABEL, SINGLE-DOSE, NON-RANDOMIZED STUDY TO EVALUATE PHARMACOKINETICS AND PHARMACODYNAMICS OF EDOXABAN IN PEDIATRIC PATIENTS.
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EP-034
POPULATION PHARMACOKINETICS AND PHARMACODYNAMICS OF EDOXABAN IN PEDIATRIC PATIENTS.
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EP-035
MECHANISTIC POPULATION PHARMACOKINETIC MODELLING OF RISDIPLAM FOR EXTRAPOLATION OF EXPOSURE AND CYP3A DRUG-DRUG INTERACTION IN NEONATES WITH SPINAL MUSCULAR ATROPHY.
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PI-102
POST MARKETING COMMITMENT OR REQUIREMENT (PMC/R) FOR RECENT APPROVED DRUG PRODUCTS: SUMMARY FROM CLINICAL PHARMACOLOGY (CP) PERSPECTIVES.
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EP-036
ESTIMATING TARGET ENGAGEMENT USING SINGLE POST-DOSE TIMEPOINT TO SUPPORT FURTHER CLINICAL DEVELOPMENT.
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LB-001
POSITIVE CORRELATION BETWEEN ORGANIC ANION TRANSPORTER 1B FUNCTION INDICATED BY PLASMA CONCENTRATION OF COPROPORPHYRIN-I AND BLOOD CONCENTRATION OF CYCLOSPORIN A IN REAL-WORLD PATIENTS.
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LB-002
RESIDUAL C-PEPTIDE IS ASSOCIATED WITH LOWER HYPOGLYCEMIA RISK IN NEW-ONSET TYPE 1 DIABETES – A POOLED ANALYSIS OF 2780 ADULTS AND CHILDREN.
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LB-003
A PHASE I, RANDOMIZED, OPEN-LABEL, CROSSOVER, FIXED-SEQUENCE STUDY TO EVALUATE THE PK, D0SE-PROPORTIONALITY, BIOAVAILABILITY, AND TOLERABILITY OF SUBCUTANEOUS LEVOTHYROXINE SODIUM (XP-8121) IN HEALTHY ADULT SUBJECTS.
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LB-004
MOLNUPIRAVIR EXPOSURE-RESPONSE OF CLINICAL OUTCOMES IN TREATMENT OF COVID-19.
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LB-005
MOLNUPIRAVIR EXPOSURE-RESPONSE RELATIONSHIPS FOR CLINICAL OUTCOMES, VIROLOGY, AND MECHANISM OF ACTION BIOMARKERS ARE CONSISTENT IN TREATMENT OF COVID-19.
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LB-006
EFFECTS OF ANTIOXIDANTS IN DRUGS PRODUCTS ON INTESTINAL DRUG TRANSPORTERS.
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LB-007
A POPULATION PHARMACOKINETIC/PHARMACODYNAMIC MODEL FOR CARFILZOMIB IN COMBINATION WITH IFOSFAMIDE, CARBOPLATIN AND ETOPOSIDE IN PATIENTS WITH RELAPSED/REFRACTORY DIFFUSE LARGE B CELL LYMPHOMA.
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LB-008
DEVELOPMENT OF HOLISTIC EXPOSURE-TOXICITY RELATIONSHIPS FOR MMAE-BASED ADCS: A GENERALIZED PK/PD MODEL.
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LB-009
IMPACT OF INTRAMUSCULAR INJECTION SITE ON SOTROVIMAB PHARMACOKINETICS.
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LB-010
PEDIATRIC POPULATION PHARMACOKINETIC MODEL DEVELOPMENT FOR ORAL AMOXICILLIN AND CLAVULANIC: LEVERAGING LITERATURE DATA FOR MODEL-INFORMED DRUG EXPOSURE ANALYSIS IN YOUNG CHILDREN.
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LB-011
THE EFFECT OF NASAL CONGESTION ON THE BIOAVAILABILITY OF INTRANASALLY ADMINISTERED EPINEPHRINE IN HEALTHY ADULT SUBJECTS WITH SEASONAL ALLERGIES.
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LB-012
ETHANOL AS AN EXCIPIENT IN DRUG FORMULATIONS ADMINISTERED TO NEONATES: PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELING TO INFORM SAFETY.
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LB-013
PHYSIOLOGICALLY BASED ABSORPTION AND PHARMACOKINETIC MODEL FOR RIVOCERANIB AND ITS MAIN METABOLITE TO ASSESS POTENTIAL CYP3A4-MEDIATED DDI RISK.
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LB-014
POPULATION PHARMACOKINETIC ANALYSIS OF PHASE 1 SUBCUTANEOUS LEVOTHYROXINE FORMULATION (XP-8121).
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LB-015
A TRANSLATIONAL COMPUTATIONAL MODEL OF ALLERGEN CHALLENGE TO SUPPORT THE CLINICAL DEVELOPMENT OF AN INTRANASALLY ADMINISTERED BACTERIAL LYSATE IN MILD ASTHMA.
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LB-016
EFFECTIVENESS OF HIGH DOSE VERSUS STANDARD DOSE INFLUENZA VACCINES IN OLDER ADULTS : INSIGHTS FROM A MULTI-STRAIN MODELING APPROACH TAKING ANTIGENIC DISTANCE INTO ACCOUNT.
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PI-001
ASSOCIATION BETWEEN BLEEDING RISK AND INITIAL P2Y12 INHIBITOR SELECTION AND DE-ESCALATION AMONG PATIENTS WITH ACUTE CORONARY SYNDROME (ACS) AND PERCUTANEOUS CORONARY INTERVENTION (PCI).
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PI-002
FENO AND SMOKING HISTORY, NOT EOSINOPHILIA, MAY PREDICT THE EFFICACY OF TIOTROPIUM (SPIRIVA RESPIMAT) IN UNCONTROLLED ASTHMA PATIENTS DESPITE ICS/LABA TREATMENT: A PILOT STUDY.
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PI-003
PDE5 INHIBITORS AND DEMENTIA RISK: A REAL-WORLD STUDY.
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PI-004
SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF A NOVEL MACROCYCLIC GADOLINIUM-BASED CONTRAST AGENT, HNP-2006, AFTER A SINGLE INTRAVENOUS ADMINISTRATION IN HEALTHY SUBJECTS.
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PI-005
USING REAL WORLD EVIDENCE (RWE) TO ASSESS DRUG-DRUG INTERACTION (DDI) BETWEEN PAXLOVID AND THE TOP 100 PRESCRIBED DRUGS IN THE US.
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PI-006
PHARMACOKINETICS AND SAFETY OF SINGLE-DOSE BEPIROVERSIN IN ADULTS WITH MODERATE HEPATIC IMPAIRMENT AND HEALTHY MATCHED CONTROLS (B-ASSURED).
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PI-007
PHARMACOKINETICS OF REMDESIVIR AND ITS METABOLITES IN PARTICIPANTS WITH MODERATE AND SEVERE HEPATIC IMPAIRMENT.
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PI-008
POPULATION MODELING OF GSK3036656 PHARMACOKINETICS AND EARLY BACTERICIDAL ACTIVITY.
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PI-009
PREDICTORS AFFECTING SPUTUM CULTURE CONVERSION IN PATIENTS WITH DRUG-SUSCEPTIBLE PULMONARY TUBERCULOSIS TREATED WITH A SHORTENED DRUG REGIMEN.
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PI-010
A DDI STUDY TO EVALUATE THE EFFECT OF MULTIPLE ORAL ADMINISTRATION OF RIFAMPICIN ON THE PHARMACOKINETICS OF VALEMETOSTAT IN HEALTHY PARTICIPANTS.
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PI-011
CHARACTERIZING THE RELATIONSHIP BETWEEN CELLULAR KINETICS AND RESPONSE TO SUPPORT DOSING RECOMMENDATIONS FOR CD19-TARGETED 19(T2)28Z1XX CELL THERAPY.
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PI-012
CLINICAL EFFICACY OF CAR-T AND CAR-NK FOR THE TREATMENT OF HEMATOLOGIC AND SOLID TUMOR MALIGNANCIES: A SYSTEMATIC REVIEW AND META-ANALYSIS.
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PI-013
COMPARISON OF PREDICTED OVERALL SURVIVAL TO OBSERVED CLINICAL DATA IN PATIENTS WITH BRAF V600-MUTANT METASTATIC MELANOMA TREATED WITH ENCORAFENIB ALONE OR ENCORAFENIB + BINIMETINIB.
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PI-014
DETERMINATION OF ABSOLUTE BIOAVAILABILITY OF QUIZARTINIB USING A MICROTRACER.
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PI-015
DEVELOPMENT OF USER-FRIENDLY BAYESIAN PREDICTIVE PLATFORM FOR BLOOD BORON-10 PHARMACOKINETICS FOLLOWING INTRAVENOUS INFUSION OF [10B]L-4-BORONOPHENYLALANINE.
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PI-016
EFFECT OF MILD AND MODERATE HEPATIC IMPAIRMENT ON QUIZARTINIB PHARMACOKINETICS.
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PI-017
ELIGIBILITY CRITERIA OF EARLY PHASE ONCOLOGY TRIALS.
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PI-018
FIRST-IN-HUMAN (FIH) HEALTHY VOLUNTEER (HV) STUDIES FOR ONCOLOGY THERAPEUTICS: A FRAMEWORK OF APPLICATION IN EARLY ONCOLOGY CLINICAL DEVELOPMENT.
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PI-019
IDENTIFICATION OF S100A9 AS A THERAPEUTIC TARGET IN PACLITAXEL-INDUCED PERIPHERIAL NEUROPATHY (PIPN).
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PI-020
IMPACT OF TYROSINE KINASE INHIBITOR (TKI) DOSAGE MODIFICATIONS ON PROGRESSION-FREE SURVIVAL (PFS) IN THE TREATMENT OF EGFR-MUTATED NON-SMALL CELL LUNG CANCER (NSCLC).
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PI-021
A RETROSPECTIVE GENOME-WIDE ASSOCIATION STUDY OF ANTIPSYCHOTIC DRUG RESPONSE IN PEDIATRIC PATIENTS WITH PSYCHIATRIC ILLNESS IN A RURAL HEALTHCARE SETTING.
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PI-022
ANALYSIS OF TICAGRELOR AND PRASUGREL CORRELATION WITH CYP2C19 GENETIC VARIANTS AS ALTERNATIVE DRUGS FOR CLOPIDOGREL.
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PI-023
CHARACTERISTICS OF PROVIDERS WHO RESPONDED TO PASSIVE CLINICAL DECISION SUPPORT ALERTS FOLLOWING PRE-EMPTIVE RETURN OF PHARMACOGENOMIC RESULTS.
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PI-024
CHRONIC NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) USE INCREASES GASTRIC TOXICITY: A PHARMACOGENOMIC ANALYSIS.
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PI-025
DOCUMENTATION OF RESULTS AND MEDICATION PRESCRIBING AFTER COMBINATORIAL PSYCHIATRIC PHARMACOGENETIC TESTING.
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PI-026
EFFECT OF CYP2D6 PHENOTYPE ON PHARMACOKINETICS OF DWN12088, A NOVEL PROLYL-TRNA SYNTHETASE INHIBITOR, IN A FIRST-IN HUMAN STUDY.
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PI-027
EFFECT OF GENETIC VARIANTS IN TSPYL ON THE PHARMACOKINETICS OF CYCLOSPORINE.
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PI-028
EVALUATING THE IMPACT OF PROTON PUMP INHIBITOR USE ON CARDIOVASCULAR OUTCOMES IN PATIENTS RECEIVING CYP2C19 GENOTYPE GUIDED ANTIPLATELET THERAPY IN A REAL-WORLD SETTING.
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PI-029
EVALUATION OF THE G6PD VARIANT C.376A>G ACTIVITY IN ALL OF US.
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PI-030
PHARMACOGENOMICS OF DILATED CARDIOMYOPATHY: POTENTIAL ROLE OF THE CDCP1 IN CARDIAC FIBROSIS.
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PI-031
PILOT, FEASIBILITY TESTING OF DPYD AND UGT1A1 PRIOR TO CHEMOTHERAPY IN A COMMUNITY-BASED CANCER CENTER.
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PI-032
THE FREQUENCY OF SLCO1B1*5 IN WOMEN OF ASIAN, NATIVE HAWAIIAN, AND PACIFIC ISLANDERS SUBGROUPS: STEPS TO INCREASE RACIAL DIVERSITY IN PHARMACOGENETIC RESEARCH.
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PI-033
A MECHANISTIC PK/PD MODEL OF AZD0171 (ANTI-LIF) TO SUPPORT PHASE 2 DOSE SELECTION.
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PI-034
A MULTI-PURPOSE FIRST-IN-HUMAN STUDY TO INVESTIGATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF ACT-777991, AN ORAL C-X-C MOTIF CHEMOKINE RECEPTOR 3 (CXCR3) ANTAGONIST.
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PI-035
A POPULATION PHARMACOKINETIC ANALYSIS OF ESCITALOPRAM AND THE EFFECT OF CYP2C19 ON CLEARANCE IN CHILDREN AND ADOLESCENTS.
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PI-036
AN IN SILICO SIMULATION STUDY OF EXTENDED INTERVAL DOSING OF ATEZOLIZUMAB USING POPULATION PHARMACOKINETICS.
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PI-037
AN OPEN-LABEL STUDY TO ASSESS THE EFFECT OF ITRACONAZOLE AND RIFAMPIN ON INCB000928 PHARMACOKINETICS WHEN ADMINISTERED ORALLY IN HEALTHY PARTICIPANTS.
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PI-038
APPLICATION OF MODELING AND SIMULATION TO EXTRAPOLATE THERAPEUTIC BUROSUMAB DOSING REGIMENS FOR SUBJECTS WITH PEDIATRIC TUMOR-INDUCED OSTEOMALCIA.
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PI-039
APPLICATION OF POPULATION PHARMACOKINETIC AND PHARMACODYNAMIC MODELING TO SUPPORT DOSAGE REGIMEN OF FESOTERODINE IN PEDIATRICS WITH NEUROLOGICAL DETRUSOR OVERACTIVITY.
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PI-040
ASSESSING THE GOLDENSEAL-METFORMIN PHARMACOKINETIC INTERACTION IN TYPE 2 DIABETICS.
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PI-041
BENEFIT-RISK OF FLAT-DOSING OF NIVOLUMAB IN COMBINATION WITH IPILIMUMAB IN THORACIC CANCER IMMUNOTHERAPY (1L METASTATIC NON-SMALL-CELL LUNG CANCER AND 1L UNRESECTABLE MALIGNANT PLEURAL MESOTHELIOMA).
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PI-042
BUDESONIDE EMBEDDED ALGINATE THIN FILMS SHOW TUNABLE SUSTAINED RELEASE.
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PI-043
CHARACTERIZATION OF GEMTUZUMAB OZOGAMICIN PHARMACOKINETICS IN ADULT PATIENTS WITH RELAPSED/REFRACTORY ACUTE MYELOID LEUKEMIA FOLLOWING FRACTIONATED DOSING REGIMEN.
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PI-044
CLINICAL DRUG–DRUG INTERACTION STUDIES TO EVALUATE THE EFFECTS OF BEMPEDOIC ACID, A SMALL-MOLECULE INHIBITOR OF ATP CITRATE LYASE, ON THE PHARMACOKINETICS OF CONCOMITANT STATIN THERAPIES.
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PI-045
COMPARATIVE PHARMACOKINETICS BETWEEN DA-2811, A DAPAGLIFLOZIN PRODRUG FORMULATION, AND CONVENTIONAL DAPAGLIFLOZIN TABLET.
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PI-046
COMPARISON OF A COLORIMETRIC ASSAY AND ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY FOR QUANTIFYING PARACETAMOL PLASMA CONCENTRATIONS: DESIGN OF A GERIATRIC PHARMACOKINETICS STUDY.
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PI-047
COMPARISON OF PATIENT-CENTRIC MICROSAMPLING VS. TRADITIONAL BLOOD SAMPLING FOR PHARMACOKINETIC ANALYSIS OF ABROCITINIB.
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PI-048
COMPARISON OF PHARMACOKINETICS AND PHARMACODYNAMICS OF HIP1802 AND NEXIUM®: A RANDOMIZED, OPEN-LABEL, MULTIPLE DOSE, CROSSOVER TRIAL.
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PI-049
COMPARISON OF THE ACID SUPPRESSION EFFECTS BETWEEN LOW-DOSE ESOMEPRAZOLE AND FAMOTIDINE IN HEALTHY SUBJECTS.
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PI-050
COMPARISON OF THE SYSTEMIC EXPOSURE AND PREDICTED INHIBITION OF PHARMACODYNAMIC CYTOKINE RESPONSE BY SYSTEMIC AND LOCALLY ACTING JAK INHIBITORS.
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PI-051
CONCENTRATION-QTC ANALYSIS TO ASSESS THE EFFECT OF THE GS-5718 ON CARDIAC REPOLARIZATION.
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PI-052
CYCLOPHOSPHAMIDE POPULATION PHARMACOKINETICS IN PEDIATRIC PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION.
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PI-053
DEVELOPING A MECHANISTIC MODEL OF IL-15 MEDIATED NK CELL PROLIFERATION WITH IMPLICATIONS IN IMPROVING CAR NK CELL THERAPY EFFICACY.
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PI-054
DEVELOPMENT OF A PHARMACOKINETIC-PHARMACODYNAMIC MODEL FOR MRNA-0184, AN INVESTIGATIONAL MRNA THERAPEUTIC ENCODING HUMAN RELAXIN-2-VLK FOR THE TREATMENT OF HEART FAILURE.
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PI-055
DOSE SELECTION FOR BRIGATINIB TO SUPPORT PEDIATRIC DEVELOPMENT.
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PI-056
DOSE SELECTION FOR MITAPIVAT PEDIATRIC PHASE 3 STUDIES USING POPULATION PHARMACOKINETIC MODELING AND SIMULATION.
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PI-057
DOSE–RESPONSE MODEL PREDICTIONS OF THE PHARMACODYNAMIC EFFECT OF BEMPEDOIC ACID, A COMPETITIVE INHIBITOR OF ATP CITRATE LYASE, IN COMBINATION WITH EZETIMIBE AND STATINS.
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PI-058
DRUG-DRUG INTERACTION POTENTIAL OF MAVACAMTEN WITH ORAL CONTRACEPTIVES: RESULTS FROM A CLINICAL PHARMACOKINETIC STUDY.
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PI-059
EARLY CLINICAL PK/PD MODELING AND SIMULATION OF ALPN-303, A POTENT DUAL BAFF/APRIL ANTAGONIST, TO SUPPORT FIRST-IN-DISEASE CLINICAL TRIALS IN SYSTEMIC LUPUS ERYTHEMATOSUS AND OTHER B CELL-RELATED DISEASES.
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PI-060
ECULIZUMAB COMPLEMENT-MEDIATED PK/PD MODEL-INFORMED SIMULATIONS REVEAL THE NEED FOR ALTERNATIVE DOSING REGIMENS DURING MAINTENANCE THERAPY FOR STEM CELL TRANSPLANT-ASSOCIATED THROMBOTIC MICROANGIOPATHY (TA-TMA).
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PI-061
EFFECT OF A MODERATE CYP3A4 INDUCER ON ENCORAFENIB IN COMBINATION WITH BINIMETINIB IN PATIENTS WITH BRAF V600-MUTANT UNRESECTABLE OR METASTATIC MELANOMA OR OTHER ADVANCED SOLID TUMORS.
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PI-062
EFFECT OF ACT-539313, A SELECTIVE OREXIN-1 RECEPTOR ANTAGONIST, ON THE CYTOCHROME P450 2C9, 2C19, AND 3A4 SUBSTRATES FLURBIPROFEN, OMEPRAZOLE, AND MIDAZOLAM USING A COCKTAIL APPROACH.
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PI-063
EFFECT OF CYP3A AND CYP2D6 GENOTYPES ON THE PHARMACOKINETICS OF OXYCODONE IN CHILDREN.
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PI-064
EFFECTS OF GLPG3970 ON SULFASALAZINE AND METHOTREXATE PHARMACOKINETICS IN HEALTHY ADULTS: RESULTS OF TWO OPEN-LABEL, PHASE I, DRUG–DRUG INTERACTION STUDIES.
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PI-066
ETEPLIRSEN, GOLODIRSEN, AND CASIMERSEN SHOW CONSISTENT CLINICAL PHARMACOLOGY PROPERTIES FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY.
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PI-067
EVALUATION OF CREATININE-BASED RENAL FUNCTION ESTIMATION EQUATIONS BY PHARMACOMETRIC ANALYSIS FOR ANTIBIOTICS.
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PI-068
EXPOSURE-RESPONSE (E-R) OF DUPILUMAB IN PAEDIATRIC PATIENTS WITH MODERATE-TO-SEVERE ASTHMA.
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PI-069
EXPOSURE-RESPONSE MODELING STRATEGIES IN ONCOLOGY: IMPACT OF DOSE REDUCTIONS ON INTERPRETATION OF RESULTS.
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PI-070
EXPOSURE-TARGETED MELPHALAN DOSING INDIVIDULIZATION IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS TRANSPLANT.
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PI-071
HOLISTIC INTEGRATION OF POPULATION PHARMACOKINETICS, PHARMACODYNAMICS AND SAFETY TO DEFINE RECOMMENDED DOSE FOR EXPANSION OF ATR INHIBITOR, M1774: AN ILLUSTRATION OF MODEL-INFORMED EARLY ONCOLOGY DRUG DEVELOPMENT.
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PI-072
IN VITRO AND IN VIVO POTENTIAL OF ZURANOLONE TO CAUSE CYP-MEDIATED DRUG-DRUG INTERACTIONS.
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PI-073
INTEGRATED MODEL-BASED ANALYSIS UTILIZING CO-EXPRESSED CHECKPOINT INHIBITOR DATA TO INFORM THE RECOMMENDED DOSE FOR EXPANSION (RDE) OF ANTI-TIGIT MAB M6223.
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PI-074
A PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODEL EVALUATING THE DRUG-DRUG INTERACTION (DDI) POTENTIAL BETWEEN LAMOTRIGINE (LMT) AND ACETAMINOPHEN (APAP).
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PI-075
APPLICATION OF MINIMAL PHYSIOLOGICALLY BASED PHARMACOKINETIC/PHARMACODYNAMIC MODEL FOR INSULIN.
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PI-076
CANNABIDIOL EXPOSURES IN BREASTFED INFANTS COMPARED TO CHILDREN AS PREDICTED BY PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING.
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PI-077
DEVELOPMENT AND VERIFICATION OF A PYRIDOXIC ACID PBPK MODEL TO EVALUATE BIOMARKER INFORMED ORGANIC ANION TRANSPORTERS (OAT) 1 AND 3 INHIBITION.
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PI-078
LEVERAGING A DERMAL PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL OF A TOPICAL CREAM TO EXPLORE THE BIOEQUIVALENCE SAFE SPACE FOR INFLUENTIAL FORMULATION ATTRIBUTES.
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PI-079
LEVERAGING PBPK DDI APPLICATION TO ENLIGHTEN THE MECHANISMS OF THE INTERACTION BETWEEN PHENYTOIN AND OMEPRAZOLE AND POTENTIAL IMPACT IN EPILEPTIC PATIENTS.
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PI-080
LEVERAGING PBPK-BASED ANALYSIS TO SUPPORT AN ADAPTIVE TRIAL DESIGN IN CHILDREN.
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PI-081
ELEXACAFTOR/TEZACAFTOR/IVACAFTOR (ETI) -INDUCED REACTIVE OXYGEN SPECIES (ROS) PRODUCTION IN HEPG2 CELLS: A POTENTIAL MECHANISM OF DRUG-INDUCED LIVER INJURY (DILI)
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PI-082
PLASMA METHYLMALONIC ACID CONCENTRATION IS POSITIVELY ASSOCIATED WITH METABOLIC DECOMPENSATION EVENTS IN PATIENTS WITH METHYLMALONIC ACIDEMIA.
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PI-083
CHARACTERIZATION OF THE US FOOD AND DRUG ADMINISTRATION POST-MARKETING COMMITMENTS AND REQUIREMENTS FOR PREGNANCY AND LACTATION.
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PI-084
EXPLORATION FOR EXCLUSION OF FEMALES OF REPRODUCTIVE POTENTIAL AS A BIOEQUIVALENCE STUDY POPULATION IN PRODUCT-SPECIFIC GUIDANCES FOR GENERIC DRUG DEVELOPMENT.
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PI-085
CEFEPIME PHARMACOKINETICS IN CRITICALLY ILL CHILDREN UNDERGOING CONTINUOUS RENAL REPLACEMENT THERAPY (CRRT).
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PI-086
COMPARISON OF DISEASE CHARACTERISTICS IN ADULTS AND CHILDREN WITH TYPE 2 DIABETES MELLITUS: IMPLICATION FOR ANTIDIABETIC DRUG DEVELOPMENT IN CHILDREN.
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PI-087
DEVELOPMENTAL CHANGES OF HYDROXYUREA PHARMACOKINETICS IN CHILDREN WITH SICKLE CELL ANEMIA.
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PI-088
IMPACT OF PREGNANCY ON THE PHARMACOKINETICS AND METABOLISM OF NICOTINAMIDE IN HUMANS.
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PI-089
NATIONAL MEETING ON COMMUNITY ENGAGED RESEARCH TOWARDS PRECISION MEDICINE WITH AMERICAN INDIAN AND ALASKA NATIVE PEOPLE.
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PI-090
PERCEIVED BARRIERS AND FACILITATORS FOR MODEL-INFORMED DOSING IN PREGNANCY AMONG HEALTHCARE PRACTITIONERS AND PREGNANT WOMEN: A QUALITATIVE STUDY.
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PI-091
PHARMACOKINETICS, PHARMACODYNAMICS, SAFETY, AND TOLERABILITY OF CEDIROGANT FOLLOWING SINGLE AND MULTIPLE DOSES IN JAPANESE AND CHINESE HEALTHY VOLUNTEERS.
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PI-092
RECENT TRENDS IN PEDIATRIC DOSING STRATEGY FROM 2000-2019: A NATURAL LANGUAGE PROCESSING/DRUG LABEL ANALYSIS.
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PI-093
A COMPREHENSIVE MIDD APPROACH TO ASSESS THE SAFETY AND EFFICACY OF TARGETED-THORIUM-CONJUGATES IN PATIENTS FOR EARLY DECISION MAKING.
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PI-094
A QUANTITATIVE SYSTEMS PHARMACOLOGY MODEL OF SEPSIS-INDUCED AUGMENTED RENAL CLEARANCE.
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PI-095
BLINATUMOMAB TRIMER FORMATION - INSIGHTS FROM A MECHANISTIC PKPD MODEL ON THE IMPLICATIONS FOR SWITCHING FROM INFUSION TO SUBCUTANEOUS DOSING REGIMEN IN ACUTE LYMPHOBLASTIC LEUKEMIA AND NON-HODGKIN’S LYMPHOMA.
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PI-096
DEVELOPMENT OF IMMUNO-ONCOLOGY (IO) QSP PLATFORM MODEL FOR EFFICACY PREDICTION OF CHECKPOINT INHIBITORS (CPI) AND ADC COMBINATION THERAPY IN PHASE II/III CLINICAL TRIALS.
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PI-097
CHARACTERIZING ANTIHYPERTENSIVE MEDICATION USAGE IN APPARENT TREATMENT-RESISTANT HYPERTENSION (aTRH) PATIENTS WITHIN THE STATE OF FLORIDA USING ELECTRONIC HEALTH RECORD (EHR)-BASED DATA.
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PI-098
THE MATERNAL AND PEDIATRIC PRECISION IN THERAPEUTICS (MPRINT) KNOWLEDGEBASE AND PORTAL.
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PI-099
INTERNATIONAL COMPARISON OF THE NUMBER OF PHASE 3 CLINICAL TRIALS FOR COVID-19.
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PI-100
THE DRUG-DRUG INTERACTION (DDI) EFFECT OF STEADY STATE ITRACONAZOLE EXPOSURE ON SINGLE DOSE PHARMACOKINETICS (PK) OF LAZERTINIB.
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PI-101
AN OPEN-LABEL SINGLE-DOSE STUDY TO EVALUATE THE PHARMACOKINETICS OF SOTORASIB IN HEALTHY SUBJECTS AND SUBJECTS WITH MODERATE OR SEVERE HEPATIC IMPAIRMENT.
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PI-103
EVALUATING THE CONSISTENCY AND EXTENT OF IMMUNOGENICITY REPORTING FOR RECENTLY APPROVED BIOLOGICS.
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PI-105
POPULATION PHARMACOKINETICS OF FS-1502, AN HER2 ANTIBODY-DRUG CONJUGATE (ADC), IN PATIENTS WITH HER2 EXPRESSED ADVANCED MALIGNANT SOLID TUMORS.
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PII-001
COMPARISON OF THE IMMUNOGENICITY RISK OF BIOTHERAPEUTICS ADMINISTERED VIA INTRAVENOUS VS. SUBCUTANEOUS ROUTE OF ADMINISTRATION.
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PII-002
DEVELOPMENT OF A MULTISCALE MECHNISM-BASED CELLULAR KINETIC-PHARMACODYNAMIC (CK-PD) MODEL FOR DUAL-TARGETED BICISTRONIC CAR-T CELL THERAPY.
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PII-003
INTEGRATED CELLULAR KINETIC (CK) – PHARMACODYNAMIC (PD) ANALYSIS FOR FIRST IN HUMAN DOSE-ESCALATION STUDY OF TAK-102: A GPC3 TARGETED AUTOLOGOUS CAR-T CELLS ARMORED WITH IL-7 AND CCL19.
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PII-004
PHASE 1 DEVELOPMENT OF RAVAGALIMAB, AN ANTI CD40 MONOCLONAL ANTIBODY, TO SUPPORT DOSE SELECTION FOR PHASE 2.
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PII-005
THERAPEUTIC DRUG MONITORING CAN GUIDE THE INTRAVENOUS-TO-SUBCUTANEOUS SWITCH OF INFLIXIMAB AND VEDOLIZUMAB: A PHARMACOKINETIC SIMULATION STUDY.
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PII-006
EARLY PHARMACODYNAMIC BIOMARKER DEVELOPMENT IN ADOLESCENTS WITH EATING DISORDERS.
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PII-007
EXPERIENCES OF CEREBROSPINAL FLUID COLLECTION, EITHER BY SERIAL SAMPLING OR BY LUMBER PUNCTURES, IN CLINICAL PHARMACOLOGY RESEARCH.
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PII-008
FC RECEPTOR MODULATION AND POTENTIAL IMPACT ON CLEARANCE OF IMMUNE CHECKPOINT INHIBITORS IN CANCER CACHEXIA.
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PII-009
NOVEL IN VITRO TUBERCULOSIS ASSAYS AND THEIR UTILITY IN PREDICTING IN VIVO DRUG EFFICACY.
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PII-010
THE REPLACEMENT, REDUCTION AND REFINEMENT PRINCIPLE APPLIED TO THE VINTAGE ORAL TYRAMINE CHALLENGE TEST OF MAO INHIBITORS; EVALUATION OF A REFINED AND REDUCED DESIGN WITH TYRAMINE CMAX REPLACING BLOOD PRESSURE RESPONSE.
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PII-011
DRUG-DRUG INTERACTION BETWEEN THE NOVEL SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITOR, DWP16001, WITH GEMIGLIPTIN AND METFORMIN IN HEALTHY SUBJECTS.
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PII-012
FROM RIFAMPIN TO CARBAMAZEPINE: HOW TO PROPERLY MANAGE SAFETY IN A CHANGING DRUG-DRUG-INTERACTION TRIAL LANDSCAPE.
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PII-013
IN VITRO, IN SILICO, AND CLINICAL INVESTIGATIONS OF BLU-5937 AS PERPETRATOR OF DRUG-DRUG INTERACTIONS.
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PII-014
PHARMACOKINETIC DRUG INTERACTION BETWEEN FEXUPRAZAN (DWP14012), A NOVEL POTASSIUM-COMPETITIVE ACID BLOCKER, AND NON-STEROIDAL ANTI-INFLAMMATORY DRUGS IN HEALTHY SUBJECTS.
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PII-015
PHARMACOKINETICS AND PHARMACODYNAMICS OF ENAVOGLIFLOZIN, AN SGLT-2 INHIBITOR, IN TYPE 2 DIABETES PATIENTS WITH IMPAIRED RENAL FUNCTION.
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PII-016
PHARMACOKINETICS OF SHIP1 INHIBITORS IN MICE: COMPARISON OF IN SILICO AND IN VIVO PHARMACOKINETICS.
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PII-017
REVIEW OF BISPECIFIC ANTIBODIES’ IMMUNOGENICITY IN CLINICAL DEVELOPMENT.
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PII-018
THE PHARMACODYNAMICS, PHARMACOKINETICS, AND SAFETY OF VUTIGLABRIDIN, A SYNTHETIC GLABRIDIN DERIVATIVE, AFTER MULTIPLE ADMINISTRATION IN OBESE SUBJECTS.
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PII-019
LINEZOLID REACHES TARGET SITE IN TUBERCULOUS MENINGITIS PATIENTS IRRESPECTIVE OF STANDARD OR HIGH RIFAMPIN DOSE.
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PII-020
A MATHEMATICAL MODEL FOR SELECTING REGIMEN COMPOSITION AND DURATION BASED ON PHENOTYPE FOR PATIENTS WITH DRUG-SUSCEPTIBLE TUBERCULOSIS.
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PII-021
QUANTIFYING THE EFFECTS OF ALCOHOL USE ON DRIED BLOOD SPOT CONCENTRATIONS OF SOFOSBUVIR’S ACTIVE METABOLITE, 007-TP, IN PERSONS WITH HEPATITIS C USING PHOSPHATIDYLETHANOL AS AN OBJECTIVE BIOMARKER OF ALCOHOL CONSUMPTION.
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PII-022
RIFAPENTINE EXPOSURE-RESPONSE RELATIONSHIPS ARE DIFFERENT FOR PHASE II AND PHASE III PRIMARY EFFICACY ENDPOINTS IN TUBERCULOSIS CLINICAL TRIALS.
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PII-023
RISK OF QT PROLONGATION WITH OLIGONUCLEOTIDES: A REVIEW OF PUBLISHED EVIDENCE.
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PII-024
TRANSLATIONAL MODEL-BASED META-ANALYSIS - A POWERFUL QUANTITATIVE TOOL IN DEVELOPING VACCINES AGAINST SARS-COV-2 VARIANTS.
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PII-025
UNDERSTANDING THE PK/PD RELATIONSHIP FOR THE METALLO-BETA-LACTAMASE (MBL) INHIBITOR MK-3402 AND PRELIMINARY DOSE PROJECTION FOR PATIENTS WITH MDR GRAM-NEGATIVE INFECTIONS.
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PII-026
BILE ACIDS AS POTENTIAL BIOMARKERS TO ASSESS LIVER IMPAIRMENT IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD).
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PII-027
LEVERAGING MACHINE LEARNING (ML) TO QUANTIFY CHANGES IN CELLULAR LOCALIZATION AND ZONAL DISTRIBUTION OF TRANSPORTERS IN LIVER TISSUE FROM PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE (NAFLD).
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PII-028
PACIFIC BLUE DERIVATIVES OF PACLITAXEL AS FLUORESCENT PROBES OF ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B (OATP1B) TRANSPORTERS.
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PII-029
THE EFFECTS OF RIFAMPICIN AS AN ORGANIC ANION TRANSPORTING POLYPEPTIDES INHIBITOR AND FEBUXOSTAT AS A BREAST CANCER RESISTANCE PROTEIN INHIBITOR ON PHARMACOKINETICS OF METHOTREXATE IN HEALTHY SUBJECTS.
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PII-030
IMPACT OF COMORBID PAIN, PSYCHIATRIC DIAGNOSES, AND SUBSTANCE USE DISORDERS ON OPIOID USE DISORDER TREATMENT IN PERSONS WITH AND WITHOUT HIV.
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PII-031
LONGITUDINAL EFFICACY ANALYSIS OF THE SUBLINGUAL FILM FORMULATION OF DEXMEDETOMIDINE (BXCL501) FOR THE TREATMENT OF ACUTE AGITATION ASSOCIATED WITH SCHIZOPHRENIA AND BIPOLAR DISORDER.
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PII-032
SUBSTANCE USE DISORDERS: GLUCOCORTICOID SIGNALING REGULATES THE EXPRESSION OF PTPRD IN HUMAN CNS CELLS.
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PII-033
THE EFFECTS OF AN ACUTE ORAL DOSE OF METHAMPHETAMINE ON NEURAL ACTIVATION DURING PERFORMANCE ON A MONETARY REWARD TASK IN HEALTHY ADULTS.
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PII-034
INVESTIGATION OF DRUG COMBINATIONS IN CANCER THROUGH UNBIASED IDENTIFICATION OF RECURRING DRUG RESPONSE PATTERNS IN CELL LINES.
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PII-035
MACHINE LEARNING-BASED DOSE OPTIMIZATION DESIGN INCORPORATING EXPOSURE-RESPONSE RELATIONSHIP IN CELL THERAPY.
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PII-036
MASS BALANCE AND METABOLITE IDENTIFICATION OF VALEMETOSTAT AFTER A SINGLE ORAL ADMINISTRATION IN HEALTHY MALE SUBJECTS.
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PII-037
MTD IN DRUG COMBO: AN EXPERT CURATED MTD DATA SET FOR EFFICIENT DRUG COMBINATION PHASE 1 TRIAL DESIGN.
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PII-038
MULTICENTER PHARMACOKINETIC STUDY OF PEMBROLIZUMAB FOR NON-SMALL CELL LUNG CANCER IN OLDER ADULTS AGED OVER 75 YEARS.
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PII-039
PHARMACOKINETICS OF INTESTINAL P-GLYCOPROTEIN SUBSTRATE DABIGATRAN ETEXILATE WITH AND WITHOUT CONCOMITANT QUIZARTINIB.
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PII-040
PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELLING OF VALEMETOSTAT TO INFORM DOSE RECOMMENDATIONS WHEN CO-ADMINISTERED WITH CYP3A/P-GP MODULATORS.
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PII-041
POTENTIAL STRATEGIES TO OPTIMIZE CAR-T CELL EXPOSURE IN ABSENCE OF DOSE-EXPOSURE RELATIONSHIPS LEVERAGING CELL KINETIC/DYNAMIC MODELS.
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PII-042
TRANSLATABILITY OF IN VITRO POTENCY TO CLINICALLY EFFICACIOUS EXPOSURE FOR MOLECULARLY TARGETED SMALL MOLECULE ONCOLOGY DRUGS.
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PII-043
TRANSLATIONAL FINDINGS FROM THE ONGOING FIRST-IN-HUMAN (FIH) STUDY OF UBAMATAMAB (REGN4018, MUC16XCD3 BISPECIFIC ANTIBODY [BSAB]) IN PATIENTS (PTS) WITH RECURRENT OVARIAN CANCER (OC): REGIMEN SELECTION.
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PII-044
UNDERSTANDING METHOTREXATE CONCENTRATIONS AND ASSOCIATED TOXICITIES TO GUIDE SUPPORTIVE CARE IN PATIENTS WITH NON-HODGKIN LYMPHOMA (NHL).
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PII-045
USE OF A POPULATION PHARMACOKINETIC MODELLING AND SIMULATION APPROACH TO IDENTIFY FLAT DOSES OF DOMVANALIMAB IN PHASE 3 STUDIES.
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PII-046
GENOME WIDE ASSOCIATION STUDY (GWAS) OF SECOND-GENERATION ANTIPSYCHOTICS (SGA)-INDUCED METABOLIC SYNDROME (METS) IN BIOME BIOBANK.
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PII-047
INFLAMMATION DRIVEN INHIBITION OF CYP2C19 METABOLISM OF VORICONAZOLE IN THE TREATMENT OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS.
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PII-048
INTERETHNIC DIFFRENCE IN (S)-WARAIN PHARMACOKINETICS AND EXTENT OF ANTICOAGULATION BETWEEN ETHIOPIAN AND NON-ETHIOPIAN JEWS.
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PII-049
MIRNA-125A ASSOCIATION WITH CARFILZOMIB-RELATED CARDIOVASCULAR ADVERSE EVENTS IN MULTIPLE MYELOMA PATIENTS: PROSPECTIVE OBSERVATION OF CARDIAC SAFETY WITH PROTEASOME INHIBITOR (PROTECT) STUDY.
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PII-050
PHARMACOGENOMIC-AUGMENTED DRUG THERAPY IN MAJOR DEPRESSIVE DISORDER: A SYSTEMATIC REVIEW OF GENES AND A CASE FOR ARTIFICIAL INTELLIGENCE-AIDED GENOME-WIDE PANEL DESIGN.
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PII-051
PHARMACOGENOMICS OF ACAMPROSATE AND NALTREXONE THERAPY RESPONSE IN ALCOHOL USE DISORDER (AUD)
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PII-052
PROTEOMIC ANALYSIS OF CARFILZOMIB (CFZ) RELATED HEART FAILURE IN MULTIPLE MYELOMA (MM) PATIENTS FROM PROSPECTIVE STUDY OF CARDIAC EVENTS DURING PROTEASOME INHIBITOR THERAPY (PROTECT) STUDY.
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PII-053
CONCENTRATION-QT MODELING ANALYSIS OF GEMTUZUMAB OZOGAMICIN FOLLOWING FRACTIONATED DOSING REGIMEN IN ADULT PATIENTS WITH RELAPSED OR REFRACTORY ACUTE MYELOID LEUKEMIA.
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PII-054
EFFECT OF COMPLEMENT FACTOR 5A RECEPTOR 1 (C5AR1) ANTAGONIST ACT-1014-6470 ON THE CYTOCHROME P450 2C19 AND 3A4 SUBSTRATES OMEPRAZOLE AND MIDAZOLAM IN A COCKTAIL STUDY IN HEALTHY SUBJECTS.
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PII-055
INVESTIGATING THE EFFECT OF INFORMATIVE CENSORING ON THE KAPLAN-MEIER ESTIMATE OF ENDPOINTS IN ONCOLOGY CLINICAL TRIALS.
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PII-056
LENACAPAVIR PHARMACOKINETICS AND DDI POTENTIAL WITH CO-ADMINISTERED ANTIRETROVIRALS IN PEOPLE WITH HIV.
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PII-057
LIMITED DRUG INTERACTION SUPPORTED BY PBPK MODELLING OF ETRUMADENANT (AB928), A NOVEL DUAL ADENOSINE RECEPTOR ANTAGONIST, UNDER COADMINISTRATION WITH A STRONG CYP3A4 AND P-GP INHIBITOR (ITRACONAZOLE) IN HEALTHY PARTICIPANTS.
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PII-058
LOW SENSITIVITY OF TEPOTINIB TO DRUG-DRUG INTERACTIONS WITH CYP3A4 AND P-GP MODULATORS.
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PII-060
METHOTREXATE POPULATION PHARMACOKINETICS IN PATIENTS WITH PRIMARY CNS LYMPHOMA: A SINGLE INSTITUTION RETROSPECTIVE STUDY.
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PII-061
MODEL INFORMED DRUG DEVELOPMENT (MIDD) TO SUPPORT AN ALTERNATIVE NIVOLUMAB DOSE AND SCHEDULE FOR ADVANCED MELANOMA.
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PII-062
MODEL-BASED APPROACH TO SELECT THE DOSE REGIMEN OF GBT021601, A NEXT-GENERATION SICKLE HEMOGLOBIN POLYMERIZATION INHIBITOR, IN HEALTHY VOLUNTEERS AND PATIENTS WITH SICKLE CELL DISEASE.
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PII-063
MODELING AND SIMULATION TO SUPPORT APIXABAN DOSE RECOMMENDATION FOR THROMBOEMBOLISM PREVENTION IN PEDIATRIC SUBJECTS WITH CONGENITAL OR ACQUIRED HEART DISEASE REQUIRING ANTICOAGULATION – SAXOPHONE STUDY.
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PII-064
MODELING MORTALITY OF PEDIATRIC PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION USING SUPERVISED MACHINE LEARNING.
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PII-065
OPTIMAL DOSING OF RIFAPENTINE IN NOVEL 4-MONTH HIGH-DOSE RIFAPENTINE WITH MOXIFLOXACIN REGIMEN FOR THE TREATMENT OF DRUG-SUSCEPTIBLE TUBERCULOSIS.
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PII-066
PHARMACOKINETIC AND PHARMACODYNAMIC CHARACTERISTICS OF PELUBIPROFEN TROMETHAMINE VERSUS PELUBIPROFEN IN HEALTHY SUBJECTS.
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PII-067
PHARMACOKINETIC AND PHARMACODYNAMIC MODELING ANALYSIS OF JPI-547 IN PATIENTS WITH ADVANCED SOLID TUMOR.
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PII-068
PHARMACOKINETIC AND PHARMACODYNAMIC MODELING OF OPIOID AND SEDATIVE/PSYCHOTROPIC DRUG EFFECTS ON VENTILATION AND PUPILLOMETRY.
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PII-069
PHARMACOKINETIC COMPARISON BETWEEN A FIXED-DOSE COMBINATION OF ATORVASTATIN/OMEGA-3 AND THE CORRESPONDING LOOSE COMBINATION IN HEALTHY KOREAN SUBJECTS.
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PII-070
PHARMACOKINETIC/PHARMACODYNAMIC ANALYSIS OF APIXABAN TO DETERMINE DOSING REGIMENS FOR PEDIATRIC PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA OR LYMPHOBLASTIC LYMPHOMA TREATED WITH ASPARAGINASE: ANALYSIS FROM THE PREVAPIX STUDY.
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PII-071
PHARMACOKINETICS (PK) OF HZN-825, A SMALL MOLECULE SELECTIVE ANTAGONIST OF LPAR1, AND THE EFFECT OF FOOD IN HEALTHY ADULT SUBJECTS.
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PII-072
PHARMACOKINETICS AND PHARMACODYNAMICS MODELING OF ACETAMINOPHEN AND IBUPROFEN TO EVALUATE THE TIME TO PATENT DUCTUS ARTERIOSUS CLOSURE IN PRETERM NEONATES.
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PII-073
PHARMACOKINETICS AND PHARMACODYNAMICS OF EVOGLIPTIN IN END-STAGE RENAL DISEASE PATIENTS ON HEMODIALYSIS.
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PII-074
PHARMACOKINETICS OF MIBAVADEMAB (MIBA) IN HEALTHY PARTICIPANTS: RESULTS FROM A RANDOMIZED, PHASE 1, TWO-PART, FIRST-IN-HUMAN STUDY.
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PII-075
PHARMACOMETRICS (PMX) APPROACH TO SUPPORT PEDIATRIC DOSING FOR THE PAN-PI3K INHIBITOR COPANLISIB IN CHILDREN AND ADOLESCENTS WITH RELAPSED/REFRACTORY SOLID TUMORS.
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PII-076
POPULATION PHARMACOKINETIC (PK)-PHARMACODYNAMIC (PD) MODELING OF VESATOLIMOD, A TLR7 AGONIST IN DEVELOPMENT FOR HIV CURE.
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PII-077
POPULATION PHARMACOKINETIC MODELING AND SIMULATION OF TRANEXAMIC ACID IN ADULTS TRAUMA PATIENTS.
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PII-078
POPULATION PHARMACOKINETIC MODELING OF CLOFAZIMINE: CHARACTERIZING THE IMPACT OF CRYPTOSPORIDIOSIS-ASSOCIATED DIARRHEA ON ORAL DRUG PHARMACOKINETICS IN HIV-INFECTED ADULTS.
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PII-079
POPULATION PHARMACOKINETIC MODELING OF EVEROLIMUS AND INDIVIDUALIZED DOSING DEPENDING ON PROMISING COVARIATES IN LIVER TRANSPLANT RECIPIENTS.
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PII-080
POPULATION PHARMACOKINETIC/PHARMACODYNAMIC (PK/PD) MODELING AND SIMULATION FOR TIGULIXOSTAT, A NOVEL XANTHINE OXIDASE INHIBITOR FOR THE TREATMENT OF GOUT WITH HYPERURICEMIA.
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PII-081
POPULATION PHARMACOKINETICS (PK) OF ETHAMBUTOL IN TUBERCULOSIS PATIENTS – TUBERCULOSIS TRIALS CONSORTIUM (TBTC) STUDY A5349/S31.
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PII-082
POPULATION PHARMACOKINETICS (POPPK) OF SACITUZUMAB GOVITECAN (SG) IN PATIENTS (PTS) WITH LOCALLY ADVANCED OR METASTATIC BREAST CANCER (MBC) OR OTHER SOLID TUMORS.
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PII-083
POPULATION PHARMACOKINETICS OF GS-3583 IN HEALTHY VOLUNTEERS AND PATIENTS WITH ADVANCED SOLID TUMORS.
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PII-084
POPULATION PHARMACOKINETICS OF MYCOPHENOLATE MOFETIL IN PEDIATRIC ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION PATIENTS.
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PII-085
POPULATION-BASED EFFICACY MODELING OF OMALIZUMAB IN PEDIATRIC PATIENTS WITH MODERATE TO SEVERE PERSISTENT INADEQUATELY CONTROLLED ALLERGIC ASTHMA.
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PII-086
QUANTITATIVE EFFECT OF CYP2C9 INDUCTION BY DICLOXACILLIN ON THE NARROW THERAPEUTIC DRUGS: PHENYTOIN AND WARFARIN.
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PII-087
THE EFFECT OF FOOD ON T3 AND T4 BIOAVAILABILITY AND THE DOSE PROPORTIONALITY OF ARMOUR THYROID.
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PII-088
THE EFFECT OF UGT INHIBITION ON THE PHARMACOKINETICS OF ECOPIPAM AND ITS METABOLITES.
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PII-089
THE EFFECTS OF CYP3A INDUCTION AND INHIBITION ON ZURANOLONE PHARMACOKINETICS IN HEALTHY ADULTS.
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PII-090
TRANSLATIONAL PHARMACOKINETIC-PHARMACODYNAMIC MODELING AND SIMULATION TO PREDICT EFFICACIOUS HUMAN DOSES FOR YH35324 (GI-301)
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PII-091
TRANSLATIONAL TOOL FOR PREDICTING THE EARLY BACTERICIDAL ACTIVITY OF SUTEZOLID FOR THE TREATMENT OF TUBERCULOSIS.
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PII-092
YOU MUST CHOOSE, BUT CHOOSE WISELY – PHASE 2 DOSE SELECTION FOR INBRX-109, A TETRAVALENT DEATH RECEPTOR 5 (DR5) AGONIST ANTIBODY.
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PII-093
ZURANOLONE, A NOVEL GABAA POSITIVE ALLOSTERIC MODULATOR, DOES NOT PROLONG THE QT INTERVAL.
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PII-094
4Β-OH CHOLESTEROL AS ENDOGENOUS BIOMARKER FOR CYP3A4 INDUCER DDI STUDIES – A PBPK PLATFORM FOR IN SILICO COMPOUND TESTING.
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PII-095
APPLICATION OF A PERMEABILITY-LIMITED MULTI-COMPARTMENT LIVER MODEL TO INVESTIGATE RIFAMPICIN-MEDIATED ZONAL INDUCTION OF HEPATIC OATP1B1 IN A PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) FRAMEWORK.
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PII-096
MODEL INFORMED DRUG INTERACTION STUDY DESIGN FOR VESATOLIMOD AND CYP3A/P-GP MODULATORS USING PBPK.
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PII-097
PBPK MODELING OF LUNG TISSUE PREDICTS EFFICACY OF ELEXACAFTOR/TEZACAFTOR/IVACAFTOR WITH CONCOMITANT RIFABUTIN ADMINISTRATION.
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PII-098
PBPK MODELING TO ASSESS DRUG-DRUG INTERACTION POTENTIAL OF VENGLUSTAT WITH CYP3A INHIBITORS.
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PII-099
PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL TO ASSESS THE DRUG-DRUG-GENE INTERACTION POTENTIAL OF BELZUTIFAN IN COMBINATION WITH CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS IN HEALTHY VOLUNTEERS.
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PII-100
POPULATION PHARMACOKINETIC ANALYSIS OF THE SUBLINGUAL FILM FORMULATION OF DEXMEDETOMIDINE (BXCL501) IN HEALTHY VOLUNTEERS AND ADULTS WITH SCHIZOPHRENIA OR BIPOLAR DISORDER.
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PII-101
PREDICTING CLINICAL EFFECTS OF CYP3A4 PERPETRATORS ON PIRTOBRUTINIB PHARMACOKINETICS USING PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELLING.
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PII-102
PREDICTION OF DRUG-DRUG INTERACTIONS (DDI) WITH A MODERATE CYP3A INDUCER: DEVELOPMENT AND VALIDATION OF PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODEL OF RIFABUTIN.
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PII-103
REGISTERED DIGOXIN DOSES FOR CHILDREN DO NOT LEAD TO OPTIMAL EXPOSURE: A PBPK STUDY.
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PII-104
INDIVIDUAL DOSE OPTIMIZATION FOR SOMATROGON BY MODELING AND SHINY INTERFACE.
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PII-105
INVESTIGATION OF THE BIOTRANSFORMATION OF TRIHEXYPHENIDYL AND APPLICATION TO DYSTONIC CEREBRAL PALSY.
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PII-106
PLASMA 3-HYDROXYPROPIONIC ACID CONCENTRATION IS POSITIVELY ASSOCIATED WITH METABOLIC DECOMPENSATION EVENTS IN PATIENTS WITH PROPIONIC ACIDEMIA.
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PII-107
A SURVEY OF REGRESSION ANALYSIS METHODS ADOPTED IN RENAL IMPAIRMENT STUDIES.
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PII-108
HUMAN RADIOLABELED MASS BALANCE STUDIES SUPPORTING NEW DRUGS APPROVAL BY THE FDA BETWEEN 2019 TO JUNE 2022.
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PII-109
PATTERNS OF USING ANTIDIABETIC MEDICATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN KOREA WITH AND WITHOUT CHRONIC KIDNEY DISEASES: MULTI-INSTITUTIONAL, REAL-WORLD DATA ANALYSIS USING THE OMOP COMMON DATA MODEL.
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PII-110
US FDA POSTMARKETING REQUIREMENTS AND COMMITMENTS RELATED TO DRUG DISPOSITION IN LACTATION AND PREGNANCY.
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PII-111
EVALUATION OF SEX DIFFERENCES IN MEDICATION PRESCRIBING RECOMMENDATIONS AND OCCURRENCE OF ADVERSE EVENTS.
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PII-112
MAGNETIC RESONANCE IMAGE-BASED ESTIMATES OF HEPATIC BLOOD FLOW IN CHILDREN WITH AND WITHOUT OBESITY; IMPLICATIONS FOR PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELS.
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PII-113
PHARMACOKINETICS OF AUMOLERTINIB IN HEALTHY CHINESE SUBJECTS AND NON-CHINESE SUBJECTS.
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PII-114
PHARMACOKINETICS, SAFETY, AND TOLERABILITY OF UPADACITINIB IN CHILDREN WITH ATOPIC DERMATITIS.
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PII-115
PHARMACOMETABOLOMICS OF STATIN DISPOSITION AND RESPONSE IN CHILDREN.
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PII-116
PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING FOR DEVELOPMENT AND APPLICATIONS OF A VIRTUAL CELIAC DISEASE POPULATION USING FELODIPINE AS A MODEL DRUG.
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PII-117
PIPERACILLINE PHARMACOKINETICS AND PHARMACODYNAMICS IN PEDIATRIC PATIENTS WHO RECEIVED HIGH FREQUENCY PIPERACILLIN/TAZOBACTAM DOSING DURING SURGERY.
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PII-118
PROTEOMIC- AND BIOINFORMATIC- BASED CHARACTERIZATION OF A PRECLINICAL RODENT MODEL OF PREECLAMPSIA.
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PII-119
THE IMPACT OF PARENT-OF-ORIGIN ON CHILDHOOD GROWTH TRAJECTORIES AND SULFONYLUREAS USE IN CHILDREN WITH HNF1A-MODY IN THE U.S. MONOGENIC DIABETES REGISTRY.
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PII-120
AN INTERIM PHARMACOKINETIC (PK) ANALYSIS OF CANNABINOIDS IN SERUM OF VOLUNTEERS RECEIVING COSMETIC HEMP EXTRACT VIA THE ORAL OR TOPICAL ROUTES.
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PII-121
CONTRIBUTION OF INFLAMMATION AND OBESITY TO VARIABILITY IN MIDAZOLAM PHARMACOKINETICS IN CHILDREN.
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PII-122
EFFECT OF THE CHOLESTYRAMINE-INDUCED ALTERATION OF BILE ACID POOL IN THE GUT ON THE PHARMACODYNAMICS OF METFORMIN: AN EXPLORATORY STUDY.
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PII-123
A MODEL-BASED META-ANALYSIS TO ASSESS THE SIMILARITIES AND DIFFERENCES OF CLINICAL SAFETY OF TARGETED-THORIUM-CONJUGATES IN PATIENTS.
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PII-124
APPLICATION OF MACHINE LEARNING (ML) ON QSP VIRTUAL PATIENT POPULATION (VPOP) FOR IDENTIFICATION OF BIOMARKERS OF RESPONSE AND FOR SELECTION OF PRE-CONDITIONING REGIMEN FOR ENGINEERED T-CELL (ET-CELL) THERAPY.
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PII-125
DEVELOPMENT OF RHEUMATOID ARTHRITIS QSP MODEL FOR TRIAL SIMULATION AND PREDICTING RESPONSE TO NOVEL COMBINATIONS.
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PII-126
QUANTITATIVE SYSTEMS TOXICOLOGY (QST) MODELING USING DILISYM INFORMED SAFE DOSE SELECTION OF EMVODODSTAT IN ACUTE MYELOID LEUKEMIA (AML) PATIENTS.
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PII-127
GERIATRIC REMOTE INITIATIVE (GeRI): IMPLEMENTING REMOTE ASSESSMENTS OF TOXICITY AND FRAILTY FOR OLDER ADULTS WITH CANCER.
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PII-128
HOW DOES CLEARANCE OF ILLICITLY MANUFACTURED FENTANYL AFFECT WITHDRAWAL DURING EARLY BUPRENORPHINE TREATMENT?
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PWI-001
PBPK MODELING OF LUNG TISSUE PREDICTS EFFICACY OF ELEXACAFTOR/TEZACAFTOR/IVACAFTOR WITH CONCOMITANT RIFABUTIN ADMINISTRATION.
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PWI-002
4Β-OH CHOLESTEROL AS ENDOGENOUS BIOMARKER FOR CYP3A4 INDUCER DDI STUDIES – A PBPK PLATFORM FOR IN SILICO COMPOUND TESTING.
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PWI-003
MAGNETIC RESONANCE IMAGE-BASED ESTIMATES OF HEPATIC BLOOD FLOW IN CHILDREN WITH AND WITHOUT OBESITY; IMPLICATIONS FOR PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELS.
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PWI-004
PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING FOR DEVELOPMENT AND APPLICATIONS OF A VIRTUAL CELIAC DISEASE POPULATION USING FELODIPINE AS A MODEL DRUG.
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PWI-005
APPLICATION OF A PERMEABILITY-LIMITED MULTI-COMPARTMENT LIVER MODEL TO INVESTIGATE RIFAMPICIN-MEDIATED ZONAL INDUCTION OF HEPATIC OATP1B1 IN A PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) FRAMEWORK.
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RWE-001
USING REAL WORLD EVIDENCE (RWE) TO ASSESS DRUG-DRUG INTERACTION (DDI) BETWEEN PAXLOVID AND THE TOP 100 PRESCRIBED DRUGS IN THE US.
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RWE-002
CONCURRENT GABAPENTIN AND OPIOID USE AND RISK OF MORTALITY IN MEDICARE RECIPIENTS WITH NON-CANCER PAIN.
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RWE-003
IMPACT OF COMORBID PAIN, PSYCHIATRIC DIAGNOSES, AND SUBSTANCE USE DISORDERS ON OPIOID USE DISORDER TREATMENT IN PERSONS WITH AND WITHOUT HIV.
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RWE-004
GERIATRIC REMOTE INITIATIVE (GeRI): IMPLEMENTING REMOTE ASSESSMENTS OF TOXICITY AND FRAILTY FOR OLDER ADULTS WITH CANCER.
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RWE-005
ASSOCIATION BETWEEN BLEEDING RISK AND INITIAL P2Y12 INHIBITOR SELECTION AND DE-ESCALATION AMONG PATIENTS WITH ACUTE CORONARY SYNDROME (ACS) AND PERCUTANEOUS CORONARY INTERVENTION (PCI).
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RWE-006
OPTIMIZING LUMEFANTRINE DOSING IN YOUNG CHILDREN USING REAL WORLD DATA AND PHARMACOKINETIC/PHARMACODYNAMIC SIMULATIONS.
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RWE-007
PREDICTING LINEZOLID-INDUCED HEMATOLOGIC TOXICITIES IN REAL-WORLD PATIENTS WITH HYBRID MODELING.
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RWE-008
PDE5 INHIBITORS AND DEMENTIA RISK: A REAL-WORLD STUDY.
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RWE-009
PATTERNS OF USING ANTIDIABETIC MEDICATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN KOREA WITH AND WITHOUT CHRONIC KIDNEY DISEASES: MULTI-INSTITUTIONAL, REAL-WORLD DATA ANALYSIS USING THE OMOP COMMON DATA MODEL.
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RWE-010
CHARACTERIZING ANTIHYPERTENSIVE MEDICATION USAGE IN APPARENT TREATMENT-RESISTANT HYPERTENSION (aTRH) PATIENTS WITHIN THE STATE OF FLORIDA USING ELECTRONIC HEALTH RECORD (EHR)-BASED DATA.
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RWE-011
THE IMPACT OF PARENT-OF-ORIGIN ON CHILDHOOD GROWTH TRAJECTORIES AND SULFONYLUREAS USE IN CHILDREN WITH HNF1A-MODY IN THE U.S. MONOGENIC DIABETES REGISTRY.
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PWII-001
MODEL-BASED APPROACH TO SELECT THE DOSE REGIMEN OF GBT021601, A NEXT-GENERATION SICKLE HEMOGLOBIN POLYMERIZATION INHIBITOR, IN HEALTHY VOLUNTEERS AND PATIENTS WITH SICKLE CELL DISEASE.
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PWII-002
A MATHEMATICAL MODEL FOR SELECTING REGIMEN COMPOSITION AND DURATION BASED ON PHENOTYPE FOR PATIENTS WITH DRUG-SUSCEPTIBLE TUBERCULOSIS.
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PWII-003
TRANSLATIONAL FINDINGS FROM THE ONGOING FIRST-IN-HUMAN (FIH) STUDY OF UBAMATAMAB (REGN4018, MUC16XCD3 BISPECIFIC ANTIBODY [BSAB]) IN PATIENTS (PTS) WITH RECURRENT OVARIAN CANCER (OC): REGIMEN SELECTION.
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PWII-004
A SURVEY OF REGRESSION ANALYSIS METHODS ADOPTED IN RENAL IMPAIRMENT STUDIES.
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PWII-005
APPLICATION OF MACHINE LEARNING (ML) ON QSP VIRTUAL PATIENT POPULATION (VPOP) FOR IDENTIFICATION OF BIOMARKERS OF RESPONSE AND FOR SELECTION OF PRE-CONDITIONING REGIMEN FOR ENGINEERED T-CELL (ET-CELL) THERAPY.
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PWIV-001
EXPLORATION FOR EXCLUSION OF FEMALES OF REPRODUCTIVE POTENTIAL AS A BIOEQUIVALENCE STUDY POPULATION IN PRODUCT-SPECIFIC GUIDANCES FOR GENERIC DRUG DEVELOPMENT.
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PWIV-002
RECENT TRENDS IN PEDIATRIC DOSING STRATEGY FROM 2000-2019: A NATURAL LANGUAGE PROCESSING/DRUG LABEL ANALYSIS.
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PWIV-003
DEVELOPMENTAL CHANGES OF HYDROXYUREA PHARMACOKINETICS IN CHILDREN WITH SICKLE CELL ANEMIA.
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PWIV-004
IMPACT OF PREGNANCY ON THE PHARMACOKINETICS AND METABOLISM OF NICOTINAMIDE IN HUMANS.
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PWIV-005
THE FREQUENCY OF SLCO1B1*5 IN WOMEN OF ASIAN, NATIVE HAWAIIAN, AND PACIFIC ISLANDERS SUBGROUPS: STEPS TO INCREASE RACIAL DIVERSITY IN PHARMACOGENETIC RESEARCH.
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PWIII-001
PILOT, FEASIBILITY TESTING OF DPYD AND UGT1A1 PRIOR TO CHEMOTHERAPY IN A COMMUNITY-BASED CANCER CENTER.
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PWIII-002
PHARMACOGENOMICS OF DILATED CARDIOMYOPATHY: POTENTIAL ROLE OF THE CDCP1 IN CARDIAC FIBROSIS.
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PWIII-003
CHARACTERISTICS OF PROVIDERS WHO RESPONDED TO PASSIVE CLINICAL DECISION SUPPORT ALERTS FOLLOWING PRE-EMPTIVE RETURN OF PHARMACOGENOMIC RESULTS.
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PWIII-004
EFFECT OF CYP3A AND CYP2D6 GENOTYPES ON THE PHARMACOKINETICS OF OXYCODONE IN CHILDREN.
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PWIII-005
EVALUATING THE IMPACT OF PROTON PUMP INHIBITOR USE ON CARDIOVASCULAR OUTCOMES IN PATIENTS RECEIVING CYP2C19 GENOTYPE GUIDED ANTIPLATELET THERAPY IN A REAL-WORLD SETTING.
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